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Paulo A Ferreira Selected Research

ran-binding protein 2

9/2019Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.
1/2017Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
12/2015Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
2/2014Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.
6/2013Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
10/2012Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
9/2010Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.
11/2007The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
9/2002Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

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Paulo A Ferreira Research Topics

Disease

8Retinitis Pigmentosa (Pigmentary Retinopathy)
02/2012 - 08/2002
4Ganglion Cysts (Ganglion)
09/2019 - 09/2002
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
09/2019 - 02/2014
2Hypertrophy
09/2019 - 01/2017
2Osteogenesis Imperfecta (Lobstein Disease)
02/2014 - 06/2012
2Blindness (Hysterical Blindness)
04/2011 - 08/2002
2Glaucoma
04/2011 - 08/2009
1Respiratory Paralysis
01/2017
1Phototoxic Dermatitis (Phototoxicity)
12/2015
1Proteostasis Deficiencies
02/2014
1Brain Diseases (Brain Disorder)
06/2013
1Transverse Myelitis (Necrotizing Myelitis)
06/2013
1Neurodegenerative Diseases (Neurodegenerative Disease)
06/2013
1Neoplasms (Cancer)
06/2013
1Nervous System Diseases (Neurological Disorders)
10/2012
1Gliosis
10/2012
1Parkinson Disease (Parkinson's Disease)
10/2012
1Parkinsonian Disorders (Parkinsonism)
10/2012
1Pathologic Processes
06/2012
1Retinal Dystrophies
02/2012
1Low Tension Glaucoma
04/2011
1Open-Angle Glaucoma (Glaucoma, Open Angle)
04/2011
1Carcinogenesis
09/2010
1Fabry Disease (Fabry's Disease)
05/2007
1Retinal Diseases
05/2005

Drug/Important Bio-Agent (IBA)

10Proteins (Proteins, Gene)FDA Link
02/2014 - 05/2005
9ran-binding protein 2IBA
09/2019 - 09/2002
8GTP Phosphohydrolases (GTPases)IBA
02/2012 - 08/2002
4Retinaldehyde (Retinal)IBA
09/2019 - 05/2005
2cyclophilin BIBA
02/2014 - 06/2012
2Biological ProductsIBA
06/2012 - 05/2005
1Carisoprodol (Soma)FDA LinkGeneric
09/2019
1ChemokinesIBA
01/2017
1Nonesterified Fatty Acids (NEFA)IBA
01/2017
1Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA
02/2014
1Cyclophilins (Cyclophilin)IBA
02/2014
1OpsinsIBA
02/2014
1ChromatinIBA
10/2012
1NeurotoxinsIBA
10/2012
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
10/2012
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2012
1ImmunophilinsIBA
06/2012
1NucleotidesIBA
02/2012
1Protein Isoforms (Isoforms)IBA
02/2012
1Biomarkers (Surrogate Marker)IBA
08/2009
1alpha-Galactosidase (Beano)IBA
05/2007
1GlycolipidsIBA
05/2007

Therapy/Procedure

1Enzyme Replacement Therapy
05/2007